MKNK1 Gene (MAPK Interacting Serine/Threonine Kinase 1)
Comprehensive genomic, expression, and functional insights into MKNK1, a key regulator of translation and oncogenic signaling.
Gene Information Card
| Symbol | MKNK1 |
|---|---|
| Full Name | MAPK interacting serine/threonine kinase 1 |
| Gene Type | gene with protein product |
| Chromosomal Location | 1p33 |
| NCBI Gene ID | 8569 ncbi.nlm.nih.gov/gene/8569 |
| Ensembl ID | ENSG00000079277 |
| UniProt ID | Q9BUB5 |
| OMIM ID | 606724 |
| HGNC ID | HGNC:7110 |
| Aliases | MNK1 |
Description
MKNK1 (MAPK interacting serine/threonine kinase 1) encodes a serine/threonine kinase that phosphorylates eukaryotic initiation factor 4E (eIF4E), a key regulator of mRNA translation. MKNK1 is activated by mitogen-activated protein kinases (MAPKs) and plays a role in cellular stress responses, proliferation, and survival. It is implicated in various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer | MKNK1 overexpression or hyperactivation promotes tumor growth by enhancing translation of oncogenic mRNAs (e.g., cyclin D1, c-Myc). | Multiple studies show elevated MKNK1 expression in various cancers; inhibition reduces tumor growth in preclinical models. |
| Inflammatory diseases | MKNK1 regulates cytokine production via eIF4E phosphorylation, contributing to inflammation. | Evidence from knockout mice and inhibitor studies. |
| Neurological disorders | MKNK1 may be involved in synaptic plasticity and neurodegeneration. | Limited evidence; further research needed. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Lung | 8.4 | Low |
| Liver | 5.1 | Low |
| Kidney | 12.3 | Medium |
| Testis | 20.5 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.7 | High expression |
| A549 | 12.4 | Moderate expression |
| MCF7 | 9.8 | Moderate expression |
| HepG2 | 6.2 | Low expression |
| K562 | 15.1 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234A>G (p.Thr412Ala) | Missense | 0.5% in TCGA | May affect kinase activity |
| c.456C>T (p.Pro152Leu) | Missense | 0.2% in gnomAD | Unknown |
| c.789_790insA (p.Glu264Lysfs*12) | Frameshift | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift or nonsense mutations that truncate the kinase domain likely result in loss of function, reducing eIF4E phosphorylation and translation.
Gain of Function (GOF)
Missense mutations in the activation loop or substrate binding site may increase kinase activity, leading to enhanced eIF4E phosphorylation and oncogenic translation.
Dominant Negative (DN)
Some mutations may produce a truncated protein that interferes with wild-type MKNK1 function, acting in a dominant-negative manner.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • ATP binding |
| • signal transduction | • regulation of translation |
| • phosphorylation |
Pathways
• MAPK signaling pathway
• mTOR signaling pathway
• Translation regulation
Protein Summary
MKNK1 is a 465-amino acid protein with an N-terminal serine/threonine kinase domain and a C-terminal MAPK binding domain. It is activated by phosphorylation by ERK or p38 MAPK. Upon activation, MKNK1 phosphorylates eIF4E at Ser209, promoting translation of mRNAs with complex 5' UTRs, many of which encode proteins involved in cell cycle and survival. MKNK1 also interacts with other proteins such as eIF4G and may have non-kinase functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MKNK1 Knockout HEK293 Cell Line | EDJ-KQ1493 | Human | 8569 | Details Get a Quote |
| MKNK1 Knockout A-549 Cell Line | EDJ-KQ21091 | Human | 8569 | Details Get a Quote |
| MKNK1 Knockout HCT 116 Cell Line | EDJ-KQ21092 | Human | 8569 | Details Get a Quote |
| MKNK1 Knockout HeLa Cell Line | EDJ-KQ21093 | Human | 8569 | Details Get a Quote |
| MKNK1 and MKNK2 Knockout HeLa Cell Line | EDC90237 | Human | 8569 and 2872 | Details Get a Quote |
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